News ID: 192189
Published: 0417 GMT May 06, 2017

Researchers cure diabetes in mice without side effects

Researchers cure diabetes in mice without side effects

Researchers at the University of Texas (UT) Health San Antonio reported they have essentially cured type 1 diabetes in laboratory mice by using gene transfer.

The discovery increases the types of pancreatic cells that secrete insulin, which represents a potential cure for type 1 diabetes and could end insulin dependence in type 2 diabetes, UPI reported.

Insulin used by the body to lower blood sugar is only made by beta cells. In type 1 diabetes, the immune system destroys beta cells resulting in the body producing no insulin.

In type 2 diabetes, the beta cells fail and insulin decreases but is still produced by the body.

Researchers at UT Health San Antonio received a US patent in January on the technique and plan to begin commercialization in the future.

The technique, known as gene transfer, involves using a virus as a vector to carry selected genes into the pancreas, which then are incorporated and cause digestive system and other cell types to make insulin.

Gene transfer using a viral vector is a process that has been approved for use by the US Food and Drug Administration, or FDA, to treat various diseases.

 

Dr. Ralph DeFronzo, professor of medicine and chief of the Division of Diabetes at UT Health, said, "The pancreas has many other cell types besides beta cells, and our approach is to alter these cells so that they start to secrete insulin, but only in response to glucose [sugar].

"This is basically just like beta cells."

In type 1 diabetes, the body rejects beta cells, however, other cell populations in the pancreas co-exist with the body's immune defenses.

DeFronzo added, "If a type 1 diabetic has been living with these cells for 30, 40 or 50 years, and all we're getting them to do is secrete insulin, we expect there to be no adverse immune response.”

The process precisely regulates blood sugar in experiments on mice, which is a major advance over traditional insulin therapy and some diabetes medications that drop blood sugar too low when not monitored closely.

Dr. Bruno Doiron, a researcher at UT Health San Antonio, said, "It worked perfectly. We cured mice for one year without any side effects.

“That's never been seen. But it's a mouse model, so caution is needed. We want to bring this to large animals that are closer to humans in physiology of the endocrine system."

Researchers hope to get to the human clinical trial phase in three years.

   
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