"Due to the exceptional circumstances caused by the spread of the virus," Lufthansa said it would scrap 23,000 flights between March 29 and April 24, with more "expected in the coming weeks".
Up to now, Lufthansa had detailed 7,100 cancellations up to the end of its winter flight plan on March 28, Presstv Reported.
Then on Friday the Frankfurt-based group, whose brands include Eurowings, Austrian Airlines and Swiss, reported "drastic declines in bookings and numerous flight cancellations", saying it would slash capacity by 50 percent in the weeks ahead.
Shares in the group fell Wednesday, trading down 1.2 percent at 10.31 euros just after 2:00 pm (1300 GMT) against a roughly flat DAX blue-chip index.
Lufthansa's subsidiary Brussels Airlines issued a statement saying it was halting all flights to and from Italy from Thursday to April 3 "due to the announcement made by the Italian government to implement further quarantine restrictions".
Coronavirus disruption has cost Lufthansa around one-third of its share price since late February.
The group said Wednesday that its "capacity adjustments mainly affect Europe, Asia and the Middle East", adding that it would aim to keep serving all destinations with at least one airline from its hubs in Frankfurt, Munich, Zurich, Vienna and Brussels.
Last week, the group said it would not fly routes to China and Iran until late April, while Israeli restrictions on non-resident arrivals from some EU countries prompted it to scrap flights there until March 28.
The group is also looking into temporarily taking "the entire Airbus A380 fleet" out of service in Frankfurt and Munich, amounting to 14 of the mammoth aircraft.
It asked passengers to check their flight status on the Lufthansa website before travelling.
Lufthansa has also instituted a hiring freeze, offered unpaid leave and is considering slashing workers' hours "to avoid dismissals".
The group is due to release its 2019 results on March 19 and will likely face questions over the expected financial impact of the epidemic.
The International Air Transport Association (IATA) recently warned the cost in in lost revenue for the industry could be in the range of $63-$100 billion.
Kuwait to halt commercial passenger flights, declare public holiday
Kuwait will halt all commercial flights to and from the Gulf Arab state starting Friday and until further notice, with the exception of cargo flights, state news agency KUNA said on Wednesday.
Authorities also announced a public holiday in the country from March 12 to March 26, with work resuming on March 29, KUNA said, adding that entities providing vital services would remain open. It said people were banned from going to restaurants and cafes, including those inside malls.