Jurgen Klopp's side will play for the first time since the Premier League was suspended in March over the COVID-19 pandemic as the title chaser makes the short trip to Merseyside rival, AFP reported.
Liverpool, 22 points clear of second placed Manchester City, needs two wins from its remaining nine games to end its 30-year wait to be crowned English champion.
If the Reds beat Everton, they can wrap up the title with another victory against Crystal Palace at Anfield on Wednesday.
Klopp's men have not been in action for 106 days and the Liverpool boss is relieved to return after talk the season might be declared null and void, which would have deprived his team of the title its superb season deserves.
Liverpool had been on course to become the first English champion to be crowned in March after recording 27 wins from 29 matches.
However, Liverpool's inevitable title will now come with an asterisk according to some pundits, who claim the Premier League's new normal of matches behind closed doors with more substitutes allowed has taken the shine off the leader’s achievements.
Klopp doesn't care about those critics and, on the eve of Liverpool's return, the German hit back.
"Now I have had a lot of time to read. I had to Google the word 'asterisk'. I only knew the word from a comic!" Klopp said.
"This is the most difficult year and season to become champions, 100 percent. It is an interrupted season, like has never happened before.
"Whoever will be champions, it will be historic because it is a year that we will never forget.
"Give us an asterisk, yes. We cannot do a lot of things that we usually can do but in this specific case at least we can say this is really special.
"That's why we enjoy the little asterisk there."
Liverpool's derby clash comes at the conclusion of a busy weekend that confirms the Premier League is back in full swing.
Following midweek matches on Wednesday and Friday, this is the first weekend since March 7 that top-flight games have been played in England.
Also on Sunday, Chelsea plays for the first time since the lockdown on when Frank Lampard's men head to struggling Villa, who escaped with a 0-0 draw in Wednesday's opener when a mistake from the Hawk-Eye goalline technology denied Sheffield United a clear goal.