The US Treasury released a statement on Wednesday, targeting the UAE-based Parthia Cargo and Delta Parts Supply FZC, Press TV reported.
Treasury Secretary Steven Mnuchin repeated the anti-Iran allegations that Mahan Air is "a tool to spread its destabilizing agenda around the world."
"The United States will continue to take action against those supporting this airline," he claimed.
The Treasury baselessly blamed the two companies "for their material support of Iranian airline Mahan Air."
"Parthia Cargo and Delta Parts Supply FZC are being designated pursuant to E.O. 13224, as amended, for having materially assisted, sponsored, or provided financial, material, or technological support for, or goods or services to or in support of, Mahan Air," read the statement.
The sanctions are part of the Trump administration's so-called maximum pressure against Iran after the US unilateral withdrawal from an internationally backed nuclear deal.