Zarif urged his Armenian and Azerbainani counterparts in separate phone calls late on Sunday to start negotiations within the framework of the international law, IRNA reported.
During his talks with Armenian Foreign Minister Zohrab Mnatsakanyan and Foreign Minister of Azerbaijan Jeyhoun Bayramov, the Iranian top diplomat also expressed concern over the ongoing situation in the region calling on both sides to exercise self-restraint, declare ceasefire and end hostilities immediately.
Zarif made the calls following the escalation of clashes between Azerbaijan and Armenia on Sunday over the volatile Nagorno-Karabakh region that reignited concern about instability in the South Caucasus.
Azerbaijan and Armenia fought a war over Nagorno-Karabakh in the 1990s. The mountainous region locates inside Azerbaijan but is run by ethnic Armenians. It broke away from Azerbaijan in a conflict that broke out as the Soviet Union collapsed in 1991.
Reports coming from Nagorno-Karabakh indicated that clashes erupted between Azerbaijan and Armenia on Sunday and both sides reported fatalities.
Zari further voiced Iran's readiness to use all its capacities to establish a ceasefire, start talks and help establish peace and tranquility in the region.
Earlier on Sunday, he said in a Twitter message that Iran is closely monitoring the alarming violence in Nagorno-Karabakh, and stressed “our region needs peace".
"Iran is closely monitoring the alarming violence in Nagorno-Karabakh," Zarif wrote on his Twitter account.
"We call for an immediate end to hostilities and urge dialogue to resolve differences.
"Our neighbors are our priority and we are ready to provide good offices to enable talks.
"Our region needs peace now," he noted.