News ID: 119651
Published: 1120 GMT June 08, 2015

Iranians develop tissue-engineered heart valves

Iranians develop tissue-engineered heart valves

Iranian researchers have created a new heart valve that combines a patient's own cells with metal alloy for a more durable replacement with potentially fewer complications.

Hamed Alavi, PhD, and Arash Kheradvar, MD and PhD, from the University of California in Irvine, developed the valve.

 Current valve replacement options are limited to those made solely from manufactured products (mechanical valves) or animal tissue (bioprosthetic valves). Mechanical heart valves tend to last longer than bioprosthetic valves, but they carry a greater long-term risk for blood clots that may lead to stroke and arterial thrombosis (clotting in the arteries), as well as bleeding from anticoagulant medications designed to prevent thrombosis, Science Daily wrote.

"Bioprosthetic valve replacements, on the other hand, are prone to limited durability, which means patients may need a reoperation usually 10 to 15 years after implantation," said Alavi.

Traditionally, tissue-engineered valves are built on a scaffold that will degrade once the tissue is more mature. Once the scaffold has degraded, however, the valve leaflets often shrink, which can cause leaks and result in valve failure.

"For our research, we decided to use a non-degradable scaffold that stays within the valve to provide the support it needs without interfering with its normal function," said Kheradvar. "The valve ― we created ― uses an ultra-flexible scaffold made of an alloy of nickel and titanium (Nitinol) that is enclosed within the patient's own cultured tissue. The entire process takes about three to eight weeks."

The researchers said that they expect the hybrid valve to self-regenerate inside the body, eventually incorporating itself into the patient's heart structure. By using the patient's own cells, the valve will become a living replacement for the diseased valve.

"We believe this new hybrid technology will significantly improve a patient's quality of life by eliminating the need for lifelong medications and without compromising the durability of the valve," said Alavi. "This is particularly beneficial for younger patients who are in need of a heart valve replacement."

 

 

   
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Resource: Science Daily
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