Health Ministry spokeswoman Sima Sadat Lari told state television that 422 patients had died from Monday to Tuesday, taking the total death toll to 36,160.
On Monday, Iran reported a record 440 COVID-19 deaths in 24 hours. Iran announced its first two deaths from the coronavirus on Feb. 19.
The spokeswoman added that at least 495,473 patients have recovered so far or have been discharged from hospitals across Iran.
Lari noted that 5,378 coronavirus patients are in critical conditions because of more severe infection.
Referring to the arrival of cold seasons in the country, she urged people to refrain from attending closed spaces and crowded places such as shopping centers as much as possible.
To stem a third wave of the virus in Iran, the government has shut schools, mosques, shops and restaurants in most of the country since early October and on Monday imposed a four-day ban on travel in and out of 25 provinces, including Tehran.
The government has also banned weddings, wakes and conferences in the Iranian capital until further notice. Tehran is the most populated city in Iran and is believed to have the highest coronavirus mortality rate.
On Saturday, President Hassan Rouhani said that new restrictions will take effect on Wednesday in 71 cities including 25 of Iran’s 31 provincial capitals for 10 days.
The head of the virology department at Masih Daneshvari Hospital in Tehran, Alireza Naji, has warned that Iran could reach 900 confirmed coronavirus deaths per day if more restrictions on movement and gatherings are not imposed.
Deputy Minister of Health Iraj Harirchi noted that the number of COVID-19 patients will rise in the coming days as the number of tests increases.
Harirchi said people should know that “the most important indicator” of the spread of the respiratory disease is “the daily death rate.”
He said between 10 and 18 percent of those hospitalized for COVID-19 have died.
IRNA and Reuters contributed to this story.