The Palestinian Red Crescent Society said at least 305 Palestinians were injured and 228 of them were taken to hospital, with several in critical condition.
Israeli soldiers in riot gear fired rubber bullets, stun grenades and tear gas at the Palestinian protesters, who in turn responded by throwing objects at them, Press TV reported.
The attack is an escalation of weeks of violence against Palestinians in Al-Quds that has reverberated across the region.
The Al-Aqsa Mosque and the Damascus Gate in Al-Quds’ Old City as well as the Sheikh Jarrah neighborhood have witnessed a spike in Israeli atrocities in recent weeks.
The latest rounds of Israeli aggression have drawn a wave of condemnations from across the globe.
UN Secretary-General Antonio Guterres expressed “deep concern” over the continuing violence in the occupied East Al-Quds, urging Israel to cease its demolition of Palestinian homes and eviction of their owners.
He also said Israel should “exercise maximum restraint and respect the right to freedom of peaceful assembly”.
The United States also voiced “serious concern” about the displacement of Palestinians from their homes in the Sheikh Jarrah neighborhood.
In Britain, Germany, Turkey, Jordan and elsewhere, people took to the streets to condemn the Israeli regime’s atrocities and voice solidarity with the Palestinian people.
Muslim nations reacted to the developments, condemning Tel Aviv for its recurring acts of aggression against Palestinians.
Iraqi Prime Minister Mustafa al-Kadhimi denounced Israel’s crackdown and said Palestinians have the right to stay in Sheikh Jarrah.
“Iraq denounces all the crimes against the Palestinian people and the prevention of the Muslim community to access their holy sites,” Kadhimi told Al Jazeera.
The Syrian Foreign Ministry also slammed evictions in the Sheikh Jarrah neighborhood as an act of “sinful aggression”, saying the actions of Tel Aviv and its settlers are “brazen and vicious aggression against the armless Palestinians”.
“Syria stresses the importance of preserving the inalienable rights of the Palestinian people based on the international law principles and the UN resolutions relevant to the Palestinian cause,” it said.
The United Arab Emirates, which normalized its relations with Israel last year, urged Israeli authorities to reduce tensions.
Jordan strongly condemned Israel’s “animalistic attack” on Palestinian worshippers, warning Israel against “continuing its barbaric behavior at Al-Aqsa”.
Qatar condemned the deployment of Israeli forces to Haram al-Sharif (the Noble Sanctuary) at the Al-Aqsa Mosque compound, calling it a provocation of millions of Muslims around the world.
“Israel must stop all measures that harm the sanctity of Al-Aqsa Mosque,” the Egyptian Foreign Ministry said in a statement, adding that building new settlements or expanding existing ones, expropriating land, or deporting Palestinians are violations of international law.
Turkey said Israel was unleashing “terror” on Palestinians and urged the regime to “immediately end its provocative and hostile stance and act with reason”.
“Israel must stop attacking Palestinians in Al-Quds and prevent the occupiers/settlers from entering the Holy Mosque. Israel bears sole responsibility for any violence,” Turkish President Recep Tayyip Erdogan’s spokesman Ibrahim Kalin said on Twitter on Monday.
“The world must act to stop this never-ending Israeli aggression against unarmed civilians in their own land.”
Pakistan’s Prime Minister Imran Khan also condemned the attack by Israeli forces against the Palestinians at the Al-Aqsa Mosque during the holy month of Ramadan.
Khan said in a Sunday tweet that Israeli attacks violate all norms of humanity and international law.