Khatibzadeh expressed concern about continuation of border conflicts between Azerbaijan and Armenia, calling on both sides to exercise self-restraint.
The Iranian spokesman stressed the need to find a peaceful settlement to the conflict.
Urging both warring sides to respect the internationally recognized borders, Khatibzadeh said Iran is ready to provide any assistance to establish sustainable peace in the region.
Conflicts sparked again between border forces of Azerbaijan and Armenia since last week when border guards of the two sides exchanged fire for several hours as tensions continue to simmer between the two countries after last year's war over the Nagorno-Karabakh region.
Both countries accused the other side of provoking the flare-up on the evening of July 19 along Armenia’s Yeraskh section of the border with Azerbaijan's Nakhchivan enclave.
The Nakhchivan is an autonomous area of Azerbaijan, governed by its own elected legislature. The region continues to suffer from the effects of the Nagorno-Karabakh conflict.
Karabakh is internationally recognized as part of Azerbaijan, but has been occupied by ethnic Armenian separatists since 1992 when they broke from Azerbaijan in a war that killed some 30,000 people.
The latest armed conflict between the two ex-Soviet republics erupted on September 27 last year and ended on November 10 through a Russian-brokered truce.