0531 GMT May 26, 2022
Aged 33, Bhutto becomes one of the world's youngest foreign ministers but inherits a diplomatic bag of issues that started well before he was born – including relations with arch-rival India, AFP reported.
Bhutto was sworn in two weeks after he helped lead an alliance that toppled Imran Khan and saw Shehbaz Sharif become prime minister.
His first foreign mission in the role will be accompanying Sharif Thursday to Saudi Arabia, a key trade partner and regular source of relief for Pakistan's struggling economy.
Bhutto is the son of assassinated former prime minister Benazir Bhutto and ex-president Asif Ali Zardari, as well as the grandson of another former premier, Zulfikar Ali Bhutto.
His grandfather also served as foreign minister in the mid-1960s and was the founder of the Pakistan Peoples Party (PPP) that Bhutto now leads.
He became party leader aged just 19, while a student at Oxford University, following his mother's assassination in 2007.
She, in turn, had taken over the party's stewardship from her mother Nusrat, who became chairwoman following the execution of her husband Zulfikar in 1979 under military dictator Zia-ul-Haq.
The new foreign minister is considered a progressive, in his mother's image, and has frequently spoken out on the rights of women and minorities.